Psychological Intervention in Adults with Difficult-to-Treat Migraine: Benefits of Applying MIDITRA Protocol

This study evaluated a tailored psychological intervention for refractory migraines, focusing on holistic well-being. Twenty-seven adult patients (24 females, 3 males) aged 23 to 70 (M= 48.33; SD=10.03) participated, assessing risk and protective factors and the intervention s impact on 23 completers. Through random assignment, participants were allocated to experimental or control groups. Results showed significant improvements post-intervention in the experimental group, including reduced disability and negative impact of headaches, and enhanced quality of life compared to baseline. They also had better outcomes in headache impact and quality of life compared to controls. Effect size analysis supported the intervention s efficacy, with improvements in positive affect, resilience, and depression. These findings emphasize the need for psychological interventions in migraine management, particularly for treatment-resistant cases. Enhanced physical and psychological parameters highlight the benefits of such interventions for patients facing substantial health challenge.