01927nas a2200289   4500000000100000008004100001260007600042653001400118653003100132653001800163653002000181653002000201653002900221653001500250653001500265653001200280653001500292100003000307700002500337700002600362245011300388300001200501490000700513520108900520022001401609020001401623       2024                            d  c12/2024bSociedad Española para el Estudio de la Ansiedad y el Estrés10aMigraines10aPsychological intervention10aMental health10aQuality of life10aCatastrophizing10aNegative headache impact10aDisability10aDepression10aAnxiety10aResilience1 aMarleska Zambrano-Camiña1 aSelene Valero-Moreno1 aMarián Pérez-Marín00aPsychological Intervention in Adults with Difficult-to-Treat Migraine: Benefits of Applying MIDITRA Protocol  a157-1660 v303 aThis study evaluated a tailored psychological intervention for refractory migraines, focusing on holistic well-being. Twenty-seven adult patients (24 females, 3 males) aged 23 to 70 (M= 48.33; SD=10.03) participated, assessing risk and protective factors and the intervention s impact on 23 completers. Through random assignment, participants were allocated to experimental or control groups. Results showed significant improvements post-intervention in the experimental group, including reduced disability and negative impact of headaches, and enhanced quality of life compared to baseline. They also had better outcomes in headache impact and quality of life compared to controls. Effect size analysis supported the intervention s efficacy, with improvements in positive affect, resilience, and depression. These findings emphasize the need for psychological interventions in migraine management, particularly for treatment-resistant cases. Enhanced physical and psychological parameters highlight the benefits of such interventions for patients facing substantial health challenge.  a1134-7937  a2174-0437