Effect of physical exercise on the serotonergic system and behavior in rats. A systematic review

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Abstract
OBJECTIVE Perform a systematic review to know the effect of physical exercise on the serotoninergic system and behavior in rodents. SEARCH STRATEGY In March 2017 the following databases and search engines were used: Pubmed, Medline, Cinahl, Sport Discus, Scopus, Web of Science, Cochrane library and Plos One. SELECTION OF STUDIES After applying the inclusion (published trials between January 2012 and February 2017) and exclusion criteria (human work, duplicate studies and those not adjusted to the subject of study) 12 articles were analysed. SYNTHESIS OF RESULTS exercise decreases anxious behavior. As for the neurotransmitter studied, there are different results. CONCLUSIONS physical exercise exerts behavioral and cerebral changes. The effect on 5-HT neurotransmitter depends on the region or brain system studied. It increases 5HT1a levels provoking an anxiolytic effect and the resistance to the anxiogenic action of 5HT2c.
Year of Publication
2018
Journal
Ansiedad y Estrés
Volume
24
Issue
1
Number of Pages
40-46
Date Published
feb
Publisher
ISSN Number
1134-7937
URL
https://www.sciencedirect.com/science/article/pii/S1134793717300490
DOI
10.1016/J.ANYES.2017.11.002