TY - JOUR
KW - Essential hypertension
KW - Clinical trials
KW - Isolated clinical hypertension
KW - White-coat hypertension
KW - Validity
KW - Blood pressure self measurement
KW - Stress-management training
AU - María Paz García-Vera
AU - Jesús Sanz
AU - Francisco Javier Labrador
AB - In clinical trials on antihypertensive treatments, the standard procedure to select patients with essential hypertension (EH) may involve the admission of patients with white-coat or isolated clinical hypertension (ICH) that threats trial validity. Employing clinic blood pressure (BP) measurements (standard procedure) and BP self-measurements, the present study estimated the prevalence of ICH among 43 males with EH who had participated in a controlled trial on stress-management training. Diagnostic errors due to the inclusion of ICH ranged from 28% to 55%. After re-analyzing data on efficacy taking into account the type of hypertension, the results suggested that the inclusion of ICH leads one to overestimate the reductions of clinic systolic BP found at postreatment but not those of clinic diastolic BP or self-measured BP. It was concluded that the standard procedure of selection of EH patients should be supplemented by other BP measures taken outside clinic (e.g., self-measurements or ambulatory recordings).
IS - 1
M3 - Journal article
N2 - In clinical trials on antihypertensive treatments, the standard procedure to select patients with essential hypertension (EH) may involve the admission of patients with white-coat or isolated clinical hypertension (ICH) that threats trial validity. Employing clinic blood pressure (BP) measurements (standard procedure) and BP self-measurements, the present study estimated the prevalence of ICH among 43 males with EH who had participated in a controlled trial on stress-management training. Diagnostic errors due to the inclusion of ICH ranged from 28% to 55%. After re-analyzing data on efficacy taking into account the type of hypertension, the results suggested that the inclusion of ICH leads one to overestimate the reductions of clinic systolic BP found at postreatment but not those of clinic diastolic BP or self-measured BP. It was concluded that the standard procedure of selection of EH patients should be supplemented by other BP measures taken outside clinic (e.g., self-measurements or ambulatory recordings).
PB - Sociedad Española para el Estudio de la Ansiedad y el Estrés
PY - 2000
SN - 2174-0437/1134-7937
SP - 71
EP - 92
T2 - Ansiedad y Estrés
TI - The isolated clinical or white-coat hypertension problem in clinical trials on antihypertensive treatments
VL - 6
ER -