01821nas a2200253   4500000000100000008004100001260007600042653002700118653002000145653003500165653002800200653001300228653003600241653003100277100002800308700001600336700003000352245011100382300001000493490000600503520103000509022001401539020001401553       2000                            d  c01/2000bSociedad Española para el Estudio de la Ansiedad y el Estrés10aEssential hypertension10aClinical trials10aIsolated clinical hypertension10aWhite-coat hypertension10aValidity10aBlood pressure self measurement10aStress-management training1 aMaría Paz García-Vera1 aJesús Sanz1 aFrancisco Javier Labrador00aThe isolated clinical or white-coat hypertension problem in clinical trials on antihypertensive treatments  a71-920 v63 aIn clinical trials on antihypertensive treatments, the standard procedure to select patients with essential hypertension (EH) may involve the admission of patients with white-coat or isolated clinical hypertension (ICH) that threats trial validity. Employing clinic blood pressure (BP) measurements (standard procedure) and BP self-measurements, the present study estimated the prevalence of ICH among 43 males with EH who had participated in a controlled trial on stress-management training. Diagnostic errors due to the inclusion of ICH ranged from 28% to 55%. After re-analyzing data on efficacy taking into account the type of hypertension, the results suggested that the inclusion of ICH leads one to overestimate the reductions of clinic systolic BP found at postreatment but not those of clinic diastolic BP or self-measured BP. It was concluded that the standard procedure of selection of EH patients should be supplemented by other BP measures taken outside clinic (e.g., self-measurements or ambulatory recordings).  a1134-7937  a2174-0437