01507nas a2200205   4500000000100000008004100001260001800042653001200060653001400072653001300086653000900099100002200108700002800130245010100158856007200259300001000331490000700341520093900348022001401287       2018                            d  cfebbElsevier10aAnxiety10aSerotonin10aExercise10aRats1 aManuel Vega-Neira1 aMercedes Soto-González00aEffect of physical exercise on the serotonergic system and behavior in rats. A systematic review  uhttps://www.sciencedirect.com/science/article/pii/S1134793717300490  a40-460 v243 aOBJECTIVE Perform a systematic review to know the effect of physical exercise on the serotoninergic system and behavior in rodents. SEARCH STRATEGY In March 2017 the following databases and search engines were used: Pubmed, Medline, Cinahl, Sport Discus, Scopus, Web of Science, Cochrane library and Plos One. SELECTION OF STUDIES After applying the inclusion (published trials between January 2012 and February 2017) and exclusion criteria (human work, duplicate studies and those not adjusted to the subject of study) 12 articles were analysed. SYNTHESIS OF RESULTS exercise decreases anxious behavior. As for the neurotransmitter studied, there are different results. CONCLUSIONS physical exercise exerts behavioral and cerebral changes. The effect on 5-HT neurotransmitter depends on the region or brain system studied. It increases 5HT1a levels provoking an anxiolytic effect and the resistance to the anxiogenic action of 5HT2c.  a1134-7937