TY - JOUR
KW - Genetically heterogeneous rats
KW - Roman rats
KW - genetics of anxiety
KW - unlearned fear
KW - learned fear
KW - defensive profiles
AU - Regina López-Aumatell
AU - Elia Vicens-Costa
AU - Marc Guitart-Masip
AU - Esther Martínez-Membrives
AU - William Valdar
AU - Martina Johannesson
AU - Toni Cañete
AU - Gloria Blázquez
AU - Lydia Giménez-Llort
AU - Jonathan Flint
AU - Adolf Tobeña
AU - Alberto Fernández-Teruel
AB - The use of genetically heterogeneous (outbred) rodents is a unique resource for the identification and fine mapping of genetic loci (QTL) influencing biological and behavioural quantitative phenotypes, allowing the identification of quantitative genes. We present the first study of this kind carried out with genetically heterogeneous rats (N/Nih-HS; derivated from an eight-way cross of inbred strains), whose behaviour is assessed in tests evoking unlearned (Black/white box, Elevated "zero" maze) or learned (context conditioned freezing, two-way active avoidance acquisition in the shuttlebox) anxious/fearful responses. The behavioural profile of N/Nih-HS rats is more similar to that of RLA-I (anxious) rats rather than to RHA-I (low anxious) rats. Significant correlations are found among unconditioned anxiety variables and two-way active avoidance acquisition in the shuttlebox; these are partially confirmed by multiple regression analysis. "High avoider" N/Nih-HS rats show lower unlearned anxiety levels than "low avoiders". Results of this behavioural assessment of the N/Nih-HS rats are discussed in terms of their potential usefulness for present and future neurobehavioural and genetic studies of fearfulness and anxiety. (PsycINFO Database Record (c) 2016 APA, all rights reserved) (Source: journal abstract)
IS - 1
M3 - Journal Article
N2 - The use of genetically heterogeneous (outbred) rodents is a unique resource for the identification and fine mapping of genetic loci (QTL) influencing biological and behavioural quantitative phenotypes, allowing the identification of quantitative genes. We present the first study of this kind carried out with genetically heterogeneous rats (N/Nih-HS; derivated from an eight-way cross of inbred strains), whose behaviour is assessed in tests evoking unlearned (Black/white box, Elevated "zero" maze) or learned (context conditioned freezing, two-way active avoidance acquisition in the shuttlebox) anxious/fearful responses. The behavioural profile of N/Nih-HS rats is more similar to that of RLA-I (anxious) rats rather than to RHA-I (low anxious) rats. Significant correlations are found among unconditioned anxiety variables and two-way active avoidance acquisition in the shuttlebox; these are partially confirmed by multiple regression analysis. "High avoider" N/Nih-HS rats show lower unlearned anxiety levels than "low avoiders". Results of this behavioural assessment of the N/Nih-HS rats are discussed in terms of their potential usefulness for present and future neurobehavioural and genetic studies of fearfulness and anxiety. (PsycINFO Database Record (c) 2016 APA, all rights reserved) (Source: journal abstract)
PB - Sociedad Española para el Estudio de la Ansiedad y el Estrés
PY - 2009
SN - 2174-0437/1134-7937
SP - 67
EP - 84
T2 - Ansiedad y Estrés
TI - Anxiety in genetically heterogeneous rats: Towards the identification of quantitative genes for behavioural traits
VL - 15
ER -