01261nas a2200229   4500000000100000008004100001260007600042653001100118653000900129653001700138653003100155653003300186100002800219700002700247700002600274245006000300300001200360490000600372520062500378022001401003020001401017       2000                            d  c07/2000bSociedad Española para el Estudio de la Ansiedad y el Estrés10aStress10aPTSD10aAcute stress10aPTSD psychological aspects10aPTSD neurobiological aspects1 aJuan José Miguel-Total1 aHéctor González Ordi1 aEduardo López Ortega00aTowards a psychological and neurobiological integration  a255-2800 v63 aThe present paper presents a review of the psychological and neurobiological aspects associated to the development and maintenance of Post-traumatic Stress Disorder (PTSD). Main facilitating factors of the onset of PTSD, cognitive and psychophysiological aspects, and neurobiological structures and systems involved in the development and maintenance of PTSD are also reviewed. Main theoretical models both from psychological and neurobiological perspectives are also taken into account. Finally, it is highlighted the importance of integrative models which allow the joint analysis of data provided by current research.  a1134-7937  a2174-0437