02372nas a2200349   4500000000100000008004100001260007600042653003500118653001500153653002400168653001900192653001700211653002300228100002700251700002200278700002300300700003100323700001900354700002400373700001700397700002100414700002500435700001900460700001800479700003000497245011900527300001000646490000700656520133100663022001401994020001402008       2009                            d  c01/2009bSociedad Española para el Estudio de la Ansiedad y el Estrés10aGenetically heterogeneous rats10aRoman rats10agenetics of anxiety10aunlearned fear10alearned fear10adefensive profiles1 aRegina López-Aumatell1 aElia Vicens-Costa1 aMarc Guitart-Masip1 aEsther Martínez-Membrives1 aWilliam Valdar1 aMartina Johannesson1 aToni Cañete1 aGloria Blázquez1 aLydia Giménez-Llort1 aJonathan Flint1 aAdolf Tobeña1 aAlberto Fernández-Teruel00aAnxiety in genetically heterogeneous rats: Towards the identification of quantitative genes for behavioural traits  a67-840 v153 aThe use of genetically heterogeneous (outbred) rodents is a unique resource for the identification and fine mapping of genetic loci (QTL) influencing biological and behavioural quantitative phenotypes, allowing the identification of quantitative genes. We present the first study of this kind carried out with genetically heterogeneous rats (N/Nih-HS; derivated from an eight-way cross of inbred strains), whose behaviour is assessed in tests evoking unlearned (Black/white box, Elevated "zero" maze) or learned (context conditioned freezing, two-way active avoidance acquisition in the shuttlebox) anxious/fearful responses. The behavioural profile of N/Nih-HS rats is more similar to that of RLA-I (anxious) rats rather than to RHA-I (low anxious) rats. Significant correlations are found among unconditioned anxiety variables and two-way active avoidance acquisition in the shuttlebox; these are partially confirmed by multiple regression analysis. "High avoider" N/Nih-HS rats show lower unlearned anxiety levels than "low avoiders". Results of this behavioural assessment of the N/Nih-HS rats are discussed in terms of their potential usefulness for present and future neurobehavioural and genetic studies of fearfulness and anxiety. (PsycINFO Database Record (c) 2016 APA, all rights reserved) (Source: journal abstract)  a1134-7937  a2174-0437